The doses of CoQ10 and L-carnitine used were quite low compared to the typical doses recommended for migraine (300 mg/day) and doses used in inflammation studies (1000 mg to 4000 mg/day)
Authors contributions Study concept and design (TOA, CON), acquisition of data (TOA), drafting of the manuscript (TOA, CON), critical revision of the manuscript for important intellectual content (TOA, BOE, CNE, CON), administrative, technical, or material support (BOE, CNE), and study supervision (CON)
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TB-500 protocol considerations Reported dosing in the research literature: Starting dose: 500 mcg daily, subcutaneous injection Titration: Increase by 100 to 150 mcg every two weeks as tolerated Target dose: 750 to 1000 mcg daily by weeks five through twelve Weekly total: Approximately 5 mg per week at full dose Cycle length: Eight to twelve weeks, with optional extension to sixteen weeks TB-500 is typically administered once daily via subcutaneous injection, with consistent timing and systematic site rotation